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Invitrogen™ DLL4 Monoclonal Antibody (4A11F8)
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Catalog No. PIMA517069
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100 μg
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Catalog No. Quantity
PIMA517069 100 μg
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Catalog No. PIMA517069 Supplier Invitrogen™ Supplier No. MA517069
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Description

Mouse Monoclonal Antibody

MA5-17069 targets DLL4 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples. The MA5-17069 immunogen is purified recombinant fragment of human DLL4 (amino acids: 313-439) expressed in E. Coli. MA5-17069 detects DLL4 which has a predicted molecular weight of approximately 74.6kDa.

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DLL4
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 4A11F8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene Dll4
Gene Accession No. Q9NR61
Gene Alias AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341
Gene Symbols Dll4
Host Species Mouse
Immunogen Purified recombinant fragment of human DLL4 (amino acids: 313-439) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54567
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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