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Invitrogen™ DLL4 Polyclonal Antibody
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Catalog No. PA186897
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50 μg
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PA186897 50 μg
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Catalog No. PA186897 Supplier Invitrogen™ Supplier No. PA186897
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Description

Rabbit Polyclonal Antibody

Predicted to react with chimpanzee, mouse and rat based on sequence homology. A suggested positive control for immunohistochemical applications is human ovary. In Western blot, this antibody detects a band at ~74 kDa in pancreatic cell lysate. Rabbit anti Human Delta-like Protein 4 antibody detects human Delta-like protein 4 (DLL4), also known as Delta-4.

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DLL4
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with <0.1% sodium azide
Gene Dll4
Gene Accession No. Q9NR61
Gene Alias AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341
Gene Symbols Dll4
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the internal region of human DLL4.
Purification Method Affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54567
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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