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Invitrogen™ DLL4 Polyclonal Antibody
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Catalog No. PIPA546974
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100 μg
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PIPA546974 100 μg
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Catalog No. PIPA546974 Supplier Invitrogen™ Supplier No. PA546974
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Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 50% cross-reactivity with recombinant human DLL4 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DLL4
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Dll4
Gene Accession No. Q9JI71
Gene Alias AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341
Gene Symbols Dll4
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse DLL4 Ser28-Pro525.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54485
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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