Invitrogen™ DMAP1 Recombinant Rabbit Monoclonal Antibody (5Z8C8)

Catalog No.	Quantity
PIMA537907	100 μL

Catalog No. PIMA537907 Supplier Invitrogen™ Supplier No. MA537907

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: HeLa, PC-12, HepG2 Immunogen sequence: RSDLVLLYEL KQACANCEYE LQMLRHRHEA LARAGVLGGP ATPASGPGPA SAEPAVTEPG LGPDPKDTII DVVGAPLTPN SRKRRESASS SSSVKKAKKP.

DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The protein also specifically potentiates DAXX-mediated repression of glucocorticoid receptor-dependent transcription. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. DMAP1 is found in a wide variety of living organisms from yeasts to humans. The human DMAP1 gene is localized on chromosome 1p34.

Specifications

• Antigen: DMAP1
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 5Z8C8
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: DMAP1
• Gene Accession No.: Q9JI44, Q9NPF5
• Gene Alias: 1500016M21Rik; DKFZp686L09142; Dmap1; Dmtap1; DNA methyltransferase 1 associated protein 1; DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1 associated protein 1; DNMT1 associated protein-1; DNMT1-associated protein 1; DNMTAP1; EAF2; FLJ11543; KIAA1425; MAT1-mediated transcriptional repressor; MEAF2; mKIAA1425; Mmtr; RP5-891H21.2; SWC4
• Gene Symbols: DMAP1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 368-467 of human DMAP1 (Q9NPF5).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 298447, 55929, 66233
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG