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Tocris Bioscience™ DMH2
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Catalog No. 558050
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Catalog No. 558050 Supplier Tocris Bioscience™ Supplier No. 5580/50
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Description

Type I BMP receptor inhibitor

DMH2 is a type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.

Specifications

Chemical Name or Material 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
CAS 1206711-14-9
Quantity 50 mg
Target BMP and Other Activin Receptor Inhibitors
Molecular Formula C27H25N5O2
Formula Weight 451.52
Purity >98%
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