Invitrogen™ DMTF1 Isoform 1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA537916

Catalog No. PIPA537916

Description

This antibody is predicted to react with dog, pig and cow based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: DMTF1 Isoform 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DMTF1
• Gene Alias: cyclin D binding myb like transcription factor 1; cyclin D binding myb-like transcription factor 1; cyclin D binding myb-like transcription factor 1D-interacting myb-like protein; cyclin D-binding Myb-like protein; cyclin-D-binding Myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1; Dimp; D-interacting myb-like protein; Dmp1; DMTF; Dmtf1; FLJ41265; hDMP1; hDMTF1; mDmp1; MRUL
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 114485, 23857, 9988
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q66HG1, Q8CE22, Q9Y222
• Gene Symbols: DMTF1
• Immunogen: Peptide with sequence CPQNEADEIDSEDS, from the N-terminus of DMTF1 (aa 33-46).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov