Invitrogen™ DMTF1 Polyclonal Antibody

Catalog No.	Quantity
PIPA582848	100 μL

Catalog No. PIPA582848 Supplier Invitrogen™ Supplier No. PA582848

Description

Rabbit Polyclonal Antibody

Immunogen sequence: ASPTVTLTAA APASPEQIIV HALSPEHLLN TSDNVTVQCH TPRVIIQTVA TEDITSSISQ AELTVDSDIQ SSDFPEPPDA LEADTFPDEI HHPKMTVEPS FNDAHVSKFS DQNSTELMNS VMVRTEEEI Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 91%.

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: DMTF1
• Applications: ChIP Assay, Immunohistochemistry (Paraffin), Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: DMTF1
• Gene Accession No.: Q9Y222
• Gene Alias: cyclin D binding myb like transcription factor 1; cyclin D binding myb-like transcription factor 1; cyclin D binding myb-like transcription factor 1D-interacting myb-like protein; cyclin D-binding Myb-like protein; cyclin-D-binding Myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1; Dimp; D-interacting myb-like protein; Dmp1; DMTF; Dmtf1; FLJ41265; hDMP1; hDMTF1; mDmp1; MRUL
• Gene Symbols: DMTF1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human DMTF1. Recombinant protein control fragment (Product #RP-89350).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9988
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG