Invitrogen™ DMTF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595873

Catalog No. PIPA595873

Description

Immunogen sequence: VTVQCHTPRV IIQTVATEDI TSSISQAELT VDSDIQSSDF PEPPDALEAD TFPDEIHHPK MTVEPSFNDA HVSKFSDQNS TELMNSVMVR TEEEISDTDL KQEESPSDLA SAYVTEGLES PTIEEQVDQT IDDETILIVP SPHGFIQASD VIDTESVLPL TTLTDPILQH HQEESNIIGS SLGSPVSEDS KDVEDLVNCH.

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: DMTF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DMTF1
• Gene Alias: cyclin D binding myb like transcription factor 1; cyclin D binding myb-like transcription factor 1; cyclin D binding myb-like transcription factor 1D-interacting myb-like protein; cyclin D-binding Myb-like protein; cyclin-D-binding Myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1; Dimp; D-interacting myb-like protein; Dmp1; DMTF; Dmtf1; FLJ41265; hDMP1; hDMTF1; mDmp1; MRUL
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9988
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.6 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9Y222
• Gene Symbols: DMTF1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 561-760 of human DMTF1 (NP_0669683).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov