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Invitrogen™ DMTF1 Polyclonal Antibody
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Catalog No. PIPA595873
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100 μL
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PIPA595873 100 μL
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Catalog No. PIPA595873 Supplier Invitrogen™ Supplier No. PA595873
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VTVQCHTPRV IIQTVATEDI TSSISQAELT VDSDIQSSDF PEPPDALEAD TFPDEIHHPK MTVEPSFNDA HVSKFSDQNS TELMNSVMVR TEEEISDTDL KQEESPSDLA SAYVTEGLES PTIEEQVDQT IDDETILIVP SPHGFIQASD VIDTESVLPL TTLTDPILQH HQEESNIIGS SLGSPVSEDS KDVEDLVNCH.

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DMTF1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene DMTF1
Gene Accession No. Q9Y222
Gene Alias cyclin D binding myb like transcription factor 1; cyclin D binding myb-like transcription factor 1; cyclin D binding myb-like transcription factor 1D-interacting myb-like protein; cyclin D-binding Myb-like protein; cyclin-D-binding Myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1; Dimp; D-interacting myb-like protein; Dmp1; DMTF; Dmtf1; FLJ41265; hDMP1; hDMTF1; mDmp1; MRUL
Gene Symbols DMTF1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 561-760 of human DMTF1 (NP_0669683).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9988
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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