DNA Adenine Methylase Monoclonal Antibody (RB1), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA112717

Catalog No. 01-674-049

Description

DNA adenine methylase (DAM) is an enzyme that methylates adenine residues in the 4-base pair DNA sequence, GATC. This methylation reaction has been shown to be crucial in a variety of cellular processes in bacteria. These include (i) the control of initiation of DNA replication (GATC occurs 11 times in the highly conserved bacterial origin of replication sequence); (ii) methyldirected mismatch repair; (iii) control of transposition of certain transposable DNA elements; and (iv) control of gene expression. With regard to gene expression, the recent report by Heithoff et al. (Science; 284:967-970; 1999) showed that the deletion of the DAM gene rendered Salmonella typhimurium totally avirulent.

Specifications

• Antigen: DNA Adenine Methylase
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.08% sodium azide
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Target Species: Bacteria
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: RB1
• Conjugate: Unconjugated
• Gene Alias: DAM; DAM methylase
• Immunogen: Recombinant DNA Adenine Methylase protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid