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DNA G-quadruplex (G4) Mouse anti-All, Clone: 1H6, MilliporeSigma™

Catalog No. MABE1126MI Shop All MilliporeSigma Products
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MABE1126MI 100 μg
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Catalog No. MABE1126MI Supplier MilliporeSigma Supplier No. MABE1126
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Description

Mouse Monoclonal Antibody

This Anti-DNA G-quadruplex (G4) Antibody, clone 1H6 is validated for use in Immunocytochemistry, Immunohistochemistry (Paraffin), ELISA and Flow Cytometry for the detection of DNA G-quadruplex .
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNA G-quadruplex (G4)
Applications Immunocytochemistry, Immunohistochemistry (Paraffin), ELISA, Flow Cytometry
Classification Monoclonal
Clone 1H6
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Host Species Mouse
Immunogen KLH-conjugated G-quadruplex DNA derived from oligonucleotides with telomeric repeats.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics and Nuclear Function
Primary or Secondary Primary
Test Specificity Clone 1H6 binds both tetramolecular and unimolecular (intramolecular) DNA G-quadruplex (G4) structures without sequence specificity, while exhibiting significantly lower affinity toward tetramolecular RNA structure or a triplex DNA structure, and little to no affinity toward either non-G4 ssDNA or ddDNA. However, clone 1H6 does not seem to bind the [AGGG(TTAGGG)3] unimolecular G4 structure, indicating a broad selectivity toward many, but not all, DNA G4 structures (Henderson, A., et al. (2014). Nucleic Acids Res. 42(2):860-869).
Target Species All species
Content And Storage Stable for 1 year at 2-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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