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DNA Ligase IV/LIG4 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984021
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50-198-4021 100 μL
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Catalog No. 50-198-4021 Supplier Bioss Supplier No. BS1677R
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Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

Specifications

Antigen DNA Ligase IV/LIG4
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene LIG4
Gene Accession No. P49917
Gene Alias 5830471N16Rik; BOS_12728; DNA joinase; DNA ligase (ATP) 4; DNA ligase (ATP) 4-like; DNA ligase 4; DNA ligase IV; DNA repair enzyme; LIG4; LIG4S; ligase IV, DNA, ATP-dependent; LOC100340318; Polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase; tiny
Gene Symbols LIG4
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human DNA Ligase IV.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3981
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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