Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ DNA Ligase IV Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA540826

Catalog No. PIPA540826


Only null left
Add to Cart

Description

Description

Peptide sequence: DGERMQMHKD GDVYKYFSRN GYNYTDQFGA SPTEGSLTPF IHNAFKADIQ Sequence homology: Cow: 92%; Dog: 93%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 92%; Rabbit: 93%; Rat: 93%.

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DNA Ligase IV
Polyclonal
Unconjugated
LIG4
5830471N16Rik; DNA joinase; DNA ligase (ATP) 4; DNA ligase 4; DNA ligase IV; DNA repair enzyme; Lig4; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase; tiny
Rabbit
Protein A
RUO
3981
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
P49917
LIG4
Synthetic peptide directed towards the N-terminal of human LIG4 (aa 275-324).
100 μL
Primary
Human
Antibody
IgG
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.