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DNA-PK Monoclonal Antibody (42-psc (42-26, 42-27)), Invitrogen™

Catalog No. PIMA513249
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500 μL
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Catalog No. Quantity
PIMA513249 500 μL
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Catalog No. PIMA513249 Supplier Thermo Scientific Supplier No. MA513249
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Description

Mouse Monoclonal Antibody

MA5-13249 targets DNA-PKcs in GS, IF, and IHC (P) applications and shows reactivity with Human samples. The MA5-13249 immunogen is human DNA-dependent Protein Kinase purified from HeLa cells.

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNA-PK
Applications Gel Shift, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 42-psc (42-26, 42-27)
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene PRKDC
Gene Accession No. P78527
Gene Alias AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Gene Symbols PRKDC
Host Species Mouse
Immunogen Human DNA-dependent Protein Kinase purified from HeLa cells
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5591
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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