DNA-PK Monoclonal Antibody (42-psc (42-26, 42-27)), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA513249

Catalog No. PIMA513249

Description

MA5-13249 targets DNA-PKcs in GS, IF, and IHC (P) applications and shows reactivity with Human samples. The MA5-13249 immunogen is human DNA-dependent Protein Kinase purified from HeLa cells.

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.

Specifications

• Antigen: DNA-PK
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P78527
• Gene Symbols: PRKDC
• Immunogen: Human DNA-dependent Protein Kinase purified from HeLa cells
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Gel Shift, Immunohistochemistry (Paraffin)
• Clone: 42-psc (42-26, 42-27)
• Conjugate: Unconjugated
• Gene: PRKDC
• Gene Alias: AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 5591
• Content And Storage: 4° C
• Form: Liquid