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Invitrogen™ DNA-PK Polyclonal Antibody
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Catalog No. PIPA596772
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PIPA596772 100 μL
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Catalog No. PIPA596772 Supplier Invitrogen™ Supplier No. PA596772
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Description

Rabbit Polyclonal Antibody

Positive Samples: HepG2, HeLa, A-549; Cellular Location: Nucleus, nucleolus Immunogen sequence: ALRAFRSDPG LLTNTMDVFV KEPSFDWKNF EQKMLKKGGS WIQEINVAEK NWYPRQKICY AKRKLAGANP AVITCDELLL GHEKAPAFRD YVAVARGSKD.

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
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Specifications

Antigen DNA-PK
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.37 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PRKDC
Gene Accession No. P78527, P97313
Gene Alias AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Gene Symbols PRKDC
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 3987-4086 of human DNA-PKcs (NP_0088355).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19090, 5591
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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