Invitrogen™ DNA-PK Recombinant Rabbit Monoclonal Antibody (RM505)

Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA562148

Catalog No. MA562148

Description

This antibody reacts to human DNA-PKs (DNA-PK catalytic subunit).

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.

Specifications

• Antigen: DNA-PK
• Classification: Recombinant Monoclonal
• Concentration: Conc. Not Determined
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
• Gene Accession No.: P78527
• Gene Symbols: PRKDC
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5591
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: RM505
• Conjugate: Unconjugated
• Gene: PRKDC
• Gene Alias: AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
• Immunogen: A peptide corresponding to the C-terminus of human DNA-PKs ( DNA-PK catalytic subunit).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG