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MilliporeSigma™ DNA-PKcs, Mouse, Unlabeled, Clone: 3A9.1,

Catalog No. MABC1236MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABC1236MI 100 μg Unconjugated
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Catalog No. MABC1236MI Supplier MilliporeSigma™ Supplier No. MABC1236
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Description

Mouse Monoclonal Antibody

DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1; UniProt P78527; also known as DNA-PK catalytic subunit, DNA-PKcs, DNPK1, p460) is encoded by the PRKDC (also known as HYRC, HYRC1, IMD26, XRCC7) gene (Gene ID 5591) in human. DNA-PK is a heterotrimer of PRKDC and the Ku p70/YRCC6-p86/XRCC5 dimer. It acts as a molecular sensor for DNA damage and is involved in DNA non-homologous end joining required for double-strand break (DSB) repair and V(D)J recombination. Upon binding to DNA, it expresses its catalytic properties. DNA-PKcs falls into the phosphatidylinositol (PI) 3-kinase family, however, biochemical assays indicate that it phosphorylates proteins and has no detectable activity toward lipids. DNA-PKcs is displays high similarity to PI kinase family members involved in cell cycle control, DNA repair, and DNA damage responses. Deficiency of DNA-PKcs is linked to severe combined immunodeficiency characterized by reduced or absent T and B cells, recurrent candidiasis, and lower respiratory tract infections. Ref.: Hartley, KO., et al. (1995). 82, 849-856.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNA-PKcs
Applications Western Blot
Classification Monoclonal
Clone 3A9.1
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene PRKDC, HYRC, HYRC1, IMD26, XRCC7
Gene Accession No. P78527
Host Species Mouse
Immunogen GST-tagged recombinant fragment from the region between FAT and KIP-binding domain of human DNA-PKcs
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis & Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_008835
Test Specificity Clone 3A9.1 detects DNA-PK catalytic subunit (DNA-PKcs), but not the regulatory subunit (Ku). Target epitope is present in both spliced isoforms of human DNA-PKcs reported by UniProt (P78527).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only. Not for use in diagnostic procedures.

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