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Invitrogen™ DNAJB14 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA557494
Description
Immunogen sequence: RKPSGSGDQS KPNCTKDSTS GSGEGGKGYT KDQVDGVLSI NKCKNYYEVL GVTKDAGDED Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 85%.
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). [UniProt].
Specifications
DNAJB14 | |
Polyclonal | |
Unconjugated | |
Dnajb14 | |
5730496F10Rik; DnaJ (Hsp40) homolog, subfamily B, member 14; DnaJ heat shock protein family (Hsp40) member B14; dnaJ homolog subfamily B member 14; Dnajb14; EGNR9427; PRO34683; UNQ9427/PRO34683 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
499716, 70604, 79982 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q149L6, Q8TBM8 | |
Dnajb14 | |
Recombinant protein corresponding to Human DNAJB14. Recombinant protein control fragment (Product #RP-96715). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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