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Invitrogen™ DNAJB14 Polyclonal Antibody
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Catalog No. PIPA5117007
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PIPA5117007 100 μL
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Catalog No. PIPA5117007 Supplier Invitrogen™ Supplier No. PA5117007
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Description

Rabbit Polyclonal Antibody

Positive Samples: 293T, Jurkat, HeLa, MCF7, Mouse brain, Rat brain Immunogen sequence: MEGNRDEAEK CVEIAREALN AGNREKAQRF LQKAEKLYPL PSARALLEII MKNGSTAGNS PHCRKPSGSG DQSKPNCTKD STSGSGEGGK GYTKDQVDGV LSINKCKNYY EVLGVTKDAG.

Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNAJB14
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.22 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Dnajb14
Gene Accession No. Q149L6, Q8TBM8
Gene Alias 5730496F10Rik; DnaJ (Hsp40) homolog, subfamily B, member 14; DnaJ heat shock protein family (Hsp40) member B14; dnaJ homolog subfamily B member 14; Dnajb14; EGNR9427; PRO34683; UNQ9427/PRO34683
Gene Symbols Dnajb14
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DNAJB14 (NP_0010268931).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 499716, 70604, 79982
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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