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Invitrogen™ DNAL1 Polyclonal Antibody
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Catalog No. PIPA5101566
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100 μL
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PIPA5101566 100 μL
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Catalog No. PIPA5101566 Supplier Invitrogen™ Supplier No. PA5101566
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DNAL1.

DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNAL1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Dnal1
Gene Accession No. Q05A62, Q4LDG9
Gene Alias 1700010H15Rik; AW121714; axonemal dynein light chain 1; C14orf168; CILD16; DNAL1; Dnalc1; dynein axonemal light chain 1; dynein light chain 1, axonemal; dynein, axonemal, light chain 1; E330027P08Rik; LC1
Gene Symbols Dnal1
Host Species Rabbit
Immunogen A synthesized peptide derived from human DNAL1(Accession Q4LDG9), corresponding to amino acid residues K128-G178.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 105000, 83544
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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