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Invitrogen™ DNER Polyclonal Antibody
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Catalog No. PIPA599872
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100 μL
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PIPA599872 100 μL
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Catalog No. PIPA599872 Supplier Invitrogen™ Supplier No. PA599872
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DNER.

DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNER
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Dner
Gene Accession No. Q8JZM4, Q8NFT8
Gene Alias A930026D19Rik; BET; Brain EGF repeat-containing transmembrane protein; Bret; Delta and Notch-like epidermal growth factor-related receptor; delta/notch like EGF repeat containing; delta/notch-like EGF repeat containing; delta/notch-like EGF-related receptor; delta-notch-like EGF repeat-containing transmembrane; Dner; H_NH0150O02.1; LOW QUALITY PROTEIN: delta and Notch-like epidermal growth factor-related receptor; transmembrane protein Bet; UNQ26; UNQ262/PRO299; WUGSC:H_NH0150O02.1
Gene Symbols Dner
Host Species Rabbit
Immunogen A synthesized peptide derived from human DNER(Accession Q8NFT8), corresponding to amino acid residues S551-N601.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 227325, 316573, 92737
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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