Invitrogen™ DNER Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599872

Catalog No. PIPA599872

Description

Antibody detects endogenous levels of total DNER.

DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.

Specifications

• Antigen: DNER
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dner
• Gene Alias: A930026D19Rik; BET; Brain EGF repeat-containing transmembrane protein; Bret; Delta and Notch-like epidermal growth factor-related receptor; delta/notch like EGF repeat containing; delta/notch-like EGF repeat containing; delta/notch-like EGF-related receptor; delta-notch-like EGF repeat-containing transmembrane; Dner; H_NH0150O02.1; LOW QUALITY PROTEIN: delta and Notch-like epidermal growth factor-related receptor; transmembrane protein Bet; UNQ26; UNQ262/PRO299; WUGSC:H_NH0150O02.1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 227325, 316573, 92737
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8JZM4, Q8NFT8
• Gene Symbols: Dner
• Immunogen: A synthesized peptide derived from human DNER(Accession Q8NFT8), corresponding to amino acid residues S551-N601.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG