Invitrogen™ DNER Polyclonal Antibody

Catalog No.	Quantity
PIPA5120373	100 μL

Catalog No. PIPA5120373 Supplier Invitrogen™ Supplier No. PA5120373

Description

Rabbit Polyclonal Antibody

Positive test controls include: Hela, HT-29, Mouse brain, Mouse eye, Mouse small intestine, Rat brain. The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein. Immunogen sequence: PATGWTESMA PRQLQPVPAT QEPDKILPRS QATVTLPTWQ PKTGQKVVEM KWDQVEVIPD IACGNASSNS SAGGRLVSFE VPQNTSVKIR QDATASLILL W.

DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.

Specifications

• Antigen: DNER
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1.12 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: Dner
• Gene Accession No.: Q8JZM4, Q8NFT8
• Gene Alias: A930026D19Rik; BET; Brain EGF repeat-containing transmembrane protein; Bret; Delta and Notch-like epidermal growth factor-related receptor; delta/notch like EGF repeat containing; delta/notch-like EGF repeat containing; delta/notch-like EGF-related receptor; delta-notch-like EGF repeat-containing transmembrane; Dner; H_NH0150O02.1; LOW QUALITY PROTEIN: delta and Notch-like epidermal growth factor-related receptor; transmembrane protein Bet; UNQ26; UNQ262/PRO299; WUGSC:H_NH0150O02.1
• Gene Symbols: Dner
• Host Species: Rabbit
• Immunogen: Recombinant protein (or fragment).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 227325, 316573, 92737
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG