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DNER Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981951
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Catalog No. Quantity
50-198-1951 100 μL
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Catalog No. 50-198-1951 Supplier Bioss Supplier No. BS12115R
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Description

Rabbit Polyclonal Antibody

DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.

Specifications

Antigen DNER
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Dner
Gene Accession No. Q8NFT8
Gene Alias A930026D19Rik; BET; Brain EGF repeat-containing transmembrane protein; Bret; Delta and Notch-like epidermal growth factor-related receptor; delta/notch like EGF repeat containing; delta/notch-like EGF repeat containing; delta/notch-like EGF-related receptor; delta-notch-like EGF repeat-containing transmembrane; Dner; H_NH0150O02.1; LOC100339477; LOW QUALITY PROTEIN: delta and Notch-like epidermal growth factor-related receptor; transmembrane protein Bet; UNQ26; UNQ262/PRO299; WUGSC:H_NH0150O02.1
Gene Symbols Dner
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human DNER.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92737
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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