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Invitrogen™ DNMBP Polyclonal Antibody
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Catalog No. PIPA530719
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100 μL
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PIPA530719 100 μL
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Catalog No. PIPA530719 Supplier Invitrogen™ Supplier No. PA530719
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: K562. Predicted reactivity: Mouse (94%), Chimpanzee (100%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The Dynamin Binding Protein (DNMBP) gene is located on chromosome 10 and has been implicated in Alzheimer's disease due to its role in regulating the actin cytoskeleton and synaptic vesicle pools, which are critical for proper neuronal function and memory performance. DNMBP mRNA expression levels are shown to be lower in Alzheimer's brains, suggesting its potential role in cognitive decline. Genetic studies have linked DNMBP to late-onset Alzheimer's disease (AD) through its single nucleotide polymorphisms (SNPs) such as rs11190305 and rs3740058, although the results show variability across different ethnic populations regarding its association with AD risk. Additionally, research on aged rats demonstrated a correlation between DNMBP expression and long-term memory performance, indicating its significance in maintaining cognitive functions during aging.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNMBP
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene DNMBP
Gene Accession No. Q6XZF7
Gene Alias 2410003L07Rik; 2410003M15Rik; ARHGEF36; Dnmbp; dynamin binding protein; dynamin-binding protein; Kiaa1010; Scaffold protein Tuba; TUBA
Gene Symbols DNMBP
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of human DNMBP. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23268
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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