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Invitrogen™ DNMT3B Polyclonal Antibody
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Catalog No. PIPA585549
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100 μL
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Catalog No. Quantity
PIPA585549 100 μL
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Catalog No. PIPA585549 Supplier Invitrogen™ Supplier No. PA585549
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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Predicted reactivity: Pig (85%). Positive Control: HeLa, HeLa nuclear, GFP-tagged DNMT3B-transfested 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNMT3B
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.29 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Dnmt3b
Gene Accession No. Q9UBC3
Gene Alias DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase 3 beta; DNA methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA methyltransferase MmuIIIB; DNA MTase HsaIIIB; DNA MTase MmuIIIB; Dnmt3; DNMT3B; ICF; ICF1; M.HsaIIIB; m.MmuIIIB; MGC1090; MmuIIIB
Gene Symbols Dnmt3b
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of human DNMT3B. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1789, 444985
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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