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Invitrogen™ DNMT3B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532218

Catalog No. PIPA532218


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Description

Description

Recommended positive controls: Recombinant DNMT3B protein. Predicted reactivity: Human (94%), Mouse (100%), Rat (99%), Pig (95%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DNMT3B
Polyclonal
Unconjugated
Dnmt3b
DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase 3 beta; DNA methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA methyltransferase MmuIIIB; DNA MTase HsaIIIB; DNA MTase MmuIIIB; Dnmt3; DNMT3B; ICF; ICF1; M.HsaIIIB; m.MmuIIIB; MGC1090; MmuIIIB
Rabbit
Antigen affinity chromatography
RUO
13436, 1789
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
1 mg/mL
PBS with 20% glycerol and 0.01% thimerosal; pH 7
O88509, Q9UBC3
Dnmt3b
Recombinant protein fragment corresponding to a region within amino acids 601 and 889 of Mouse DNMT3B.
100 μL
Primary
Human, Mouse
Antibody
IgG
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