Dobutamine hydrochloride

Description

CAS: 49745-95-1 | C18H24ClNO3 | 337.84 g/mol

Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1M.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 μM.

Solubility
Soluble in water or ethanol with warming. Also soluble in methanol

Notes
Solutions oxidize readily at pH greater than 11. Protect solutions from light

Specifications

Chemical Identifiers

• CAS: 49745-95-1
• Molecular Formula: C18H24ClNO3
• Molecular Weight (g/mol): 337.84
• MDL Number: MFCD00153795
• InChI Key: BQKADKWNRWCIJL-UHFFFAOYNA-N
• Synonym: dobutamine hydrochloride, dobutamine hcl, dobutrex, inotrex, dl-dobutamine hydrochloride, dobutamina clorhidrato spanish, 4-2-4-4-hydroxyphenyl butan-2-ylamino ethyl benzene-1,2-diol hydrochloride, +--4-2-3-p-hydroxyphenyl-1-methylpropyl amino ethyl pyrocatechol hydrochloride, 1,2-benzenediol, 4-2-3-4-hydroxyphenyl-1-methylpropyl amino ethyl-, hydrochloride, +-
• PubChem CID: 65324
• ChEBI: CHEBI:4671
• IUPAC Name: hydrogen 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol chloride
• SMILES: [H+].[Cl-].CC(CCC1=CC=C(O)C=C1)NCCC1=CC=C(O)C(O)=C1

• Melting Point: 184°C to 186°C
• Color: White
• Quantity: 250 mg
• Merck Index: 14,3395
• Solubility Information: Soluble in water or ethanol with warming; Also soluble in methanol
• Formula Weight: 337.85
• Physical Form: Powder
• Chemical Name or Material: Dobutamine hydrochloride

Safety and Handling

Hazard Category	H302+H312+H332-H361
Hazard Statement	GHS H Statement H361-H302-H312-H332 Suspected of damaging fertility or the unborn child. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Precautionary Statement	P201-P202-P261-P264b-P270-P271-P281-P301+P312-P302+P352-P304+P340-P308+P313-P312-P330-P363-P501c
EINECSNumber	256-464-1
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only