Invitrogen™ DOCK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA543763

Catalog No. PIPA543763

Description

Peptide sequence: ALALSVAGIP GLDEANTSPR LSQTFLQLSD GDKKTLTRKK VNQFFKTMLA Sequence homology: Cow: 86%; Dog: 79%; Guinea Pig: 92%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 92%.

Dedicator of cytokinesis 2 (DOCK2) is a gene located on chromosome 5q15, encoding a member of the DOCK family of guanine nucleotide exchange factors (GEFs). DOCK2 plays a crucial role in the immune system by regulating the actin cytoskeleton, which is essential for cell movement and immune cell activation. It is predominantly expressed in hematopoietic cells, including lymphocytes and other leukocytes, where it facilitates chemotaxis and polarization by activating the small GTPase Rac. This activation is critical for processes such as lymphocyte homing, migration towards chemokines, and phagocytosis. Genetic mutations or dysregulation of DOCK2 can lead to immunodeficiency, characterized by impaired immune responses and increased susceptibility to infections. Research into DOCK2 focuses on its therapeutic potential in modulating immune responses and its role in disorders characterized by immune dysregulation, such as autoimmune diseases and chronic inflammation.

Specifications

• Antigen: DOCK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DOCK2
• Gene Alias: AI662014; AW122239; CED-5; dedicator of cytokinesis 2; dedicator of cyto-kinesis 2; dedicator of cytokinesis protein 2; DOCK2; FLJ46592; Hch; IMD40; KIAA0209; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 2; MBC; Protein Hch
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1794
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q92608
• Gene Symbols: DOCK2
• Immunogen: Synthetic peptide directed towards the middle region of human DOCK2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG