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Invitrogen™ DOCK2 Polyclonal Antibody
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Catalog No. PIPA543763
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100 μL
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PIPA543763 100 μL
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Catalog No. PIPA543763 Supplier Invitrogen™ Supplier No. PA543763
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Description

Rabbit Polyclonal Antibody

Peptide sequence: ALALSVAGIP GLDEANTSPR LSQTFLQLSD GDKKTLTRKK VNQFFKTMLA Sequence homology: Cow: 86%; Dog: 79%; Guinea Pig: 92%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 92%.

Dedicator of cytokinesis 2 (DOCK2) is a gene located on chromosome 5q15, encoding a member of the DOCK family of guanine nucleotide exchange factors (GEFs). DOCK2 plays a crucial role in the immune system by regulating the actin cytoskeleton, which is essential for cell movement and immune cell activation. It is predominantly expressed in hematopoietic cells, including lymphocytes and other leukocytes, where it facilitates chemotaxis and polarization by activating the small GTPase Rac. This activation is critical for processes such as lymphocyte homing, migration towards chemokines, and phagocytosis. Genetic mutations or dysregulation of DOCK2 can lead to immunodeficiency, characterized by impaired immune responses and increased susceptibility to infections. Research into DOCK2 focuses on its therapeutic potential in modulating immune responses and its role in disorders characterized by immune dysregulation, such as autoimmune diseases and chronic inflammation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DOCK2
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene DOCK2
Gene Accession No. Q92608
Gene Alias AI662014; AW122239; CED-5; dedicator of cytokinesis 2; dedicator of cyto-kinesis 2; dedicator of cytokinesis protein 2; DOCK2; FLJ46592; Hch; IMD40; KIAA0209; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 2; MBC; Protein Hch
Gene Symbols DOCK2
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human DOCK2.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1794
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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