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Invitrogen™ DOCK2 Polyclonal Antibody
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Catalog No. PIPA548075
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100 μg
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Catalog No. Quantity
PIPA548075 100 μg
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Catalog No. PIPA548075 Supplier Invitrogen™ Supplier No. PA548075
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Description

Goat Polyclonal Antibody

Reconstitute at 0.2 mg/mL in sterile PBS.

Dedicator of cytokinesis 2 (DOCK2) is a gene located on chromosome 5q15, encoding a member of the DOCK family of guanine nucleotide exchange factors (GEFs). DOCK2 plays a crucial role in the immune system by regulating the actin cytoskeleton, which is essential for cell movement and immune cell activation. It is predominantly expressed in hematopoietic cells, including lymphocytes and other leukocytes, where it facilitates chemotaxis and polarization by activating the small GTPase Rac. This activation is critical for processes such as lymphocyte homing, migration towards chemokines, and phagocytosis. Genetic mutations or dysregulation of DOCK2 can lead to immunodeficiency, characterized by impaired immune responses and increased susceptibility to infections. Research into DOCK2 focuses on its therapeutic potential in modulating immune responses and its role in disorders characterized by immune dysregulation, such as autoimmune diseases and chronic inflammation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DOCK2
Applications Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene DOCK2
Gene Accession No. Q92608
Gene Alias AI662014; AW122239; CED-5; dedicator of cytokinesis 2; dedicator of cyto-kinesis 2; dedicator of cytokinesis protein 2; DOCK2; FLJ46592; Hch; IMD40; KIAA0209; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 2; MBC; Protein Hch
Gene Symbols DOCK2
Host Species Goat
Immunogen E. coli-derived recombinant human DOCK2 Gly420-Gly642.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1794
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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