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DOCK3/MOCA Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501733035 Shop All Proteintech Group Inc Products
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50-173-3035 150 μL
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Catalog No. 50-173-3035 Supplier Proteintech Group Inc Supplier No. 206831AP150UL
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Description

Rabbit Polyclonal Antibody

Dedicator of cytokinesis3 (DOCK3), also named as MOCA and PBP, is a ∽180 kDa protein involved in signaling transduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3beta (GSK-3beta) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.

Specifications

Antigen DOCK3/MOCA
Applications Western Blot
Classification Polyclonal
Concentration 0.49 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene DOCK3
Gene Accession No. Q8CIQ7, Q8IZD9
Gene Alias dedicator of cytokinesis 3, DOCK3, KIAA0299, MOCA, Modifier of cell adhesion, PBP, Presenilin binding protein
Gene Symbols DOCK3
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1795, 208869
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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