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Invitrogen™ DOCK3 Polyclonal Antibody
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Catalog No. PIPA547902
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100 μg
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Catalog No. Quantity
PIPA547902 100 μg
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Catalog No. PIPA547902 Supplier Invitrogen™ Supplier No. PA547902
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Description

Sheep Polyclonal Antibody

In direct ELISAs, less than 3% cross-reactivity with recombinant human (rh) DOCK1, rhDOCK2, and rhDOCK5 is observed. Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Dedicator of cytokinesis3 (DOCK3), also named as MOCA and PBP, is a ~180 kDa protein involved in signaling transduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3beta (GSK-3beta) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DOCK3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Dock3
Gene Accession No. Q8IZD9
Gene Alias dedicator of cytokinesis 3; dedicator of cyto-kinesis 3; dedicator of cytokinesis protein 3; DOCK3; dok-3; KIAA0299; mKIAA0299; MOCA; Modifier of cell adhesion; PBP; Presenilin-binding protein
Gene Symbols Dock3
Host Species Sheep
Immunogen E. coli-derived recombinant human DOCK3 Gly418-Thr656.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1795
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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