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Invitrogen™ DOCK4 Polyclonal Antibody
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Catalog No. PIPA5119079
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Quantity:
20 μL
200 μL
Catalog No. Quantity
PIPA5119079 200 μL
PIPA5122029 20 μL
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Catalog No. PIPA5119079

Supplier: Invitrogen™ PA5119079

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Description

Rabbit Polyclonal Antibody

DOCK4 Polyclonal Antibody for Western Blot, IHC (P)

The DOCK4 gene encodes the dedicator of cytokinesis 4 protein, a member of the DOCK family, which functions as a guanine nucleotide exchange factor (GEF) for small Rho GTPases, specifically Rac1 and Rap1. DOCK4 is critical for regulating various cellular processes, including cell migration, polarity, and cytoskeletal organization. It plays a significant role in maintaining the integrity of endothelial barriers and mediating intercellular junctions. Mutations or altered expression of DOCK4 have been implicated in cancer progression, particularly in tumor metastasis and invasion, by affecting the adhesion and migration of cancer cells. Additionally, DOCK4 is involved in neurodevelopmental processes and has been associated with psychiatric disorders, reflecting its importance in brain function and development. Understanding the roles of DOCK4 in both health and disease could provide insights into therapeutic strategies for cancer and neurological disorders where these pathways are disrupted.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DOCK4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.81 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene DOCK4
Gene Accession No. Q8N1I0
Gene Alias 5330406C03; 6330411N01Rik; AF263288; C030023J22; dedicator of cytokinesis 4; dedicator of cytokinesis protein 4; DOCK4; Kiaa0716; mKIAA0716; RGD1561724
Gene Symbols DOCK4
Host Species Rabbit
Immunogen Recombinant protein Dedicator Of Cytokinesis 4. The antigen corresponds to amino acid range 1-300 of the target protein.
Purification Method Antigen affinity chromatography, Protein A
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9732
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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