Invitrogen™ DOCK4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA567177

Catalog No. PIPA567177

Description

Immunogen sequence: CSAIYPTPVEP SQRMLFNHIG DGALPRSDPN LSAPEKAVNP TPSSWSLDSG KEAKNMSDSG KLISP Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

The DOCK4 gene encodes the dedicator of cytokinesis 4 protein, a member of the DOCK family, which functions as a guanine nucleotide exchange factor (GEF) for small Rho GTPases, specifically Rac1 and Rap1. DOCK4 is critical for regulating various cellular processes, including cell migration, polarity, and cytoskeletal organization. It plays a significant role in maintaining the integrity of endothelial barriers and mediating intercellular junctions. Mutations or altered expression of DOCK4 have been implicated in cancer progression, particularly in tumor metastasis and invasion, by affecting the adhesion and migration of cancer cells. Additionally, DOCK4 is involved in neurodevelopmental processes and has been associated with psychiatric disorders, reflecting its importance in brain function and development. Understanding the roles of DOCK4 in both health and disease could provide insights into therapeutic strategies for cancer and neurological disorders where these pathways are disrupted.

Specifications

• Antigen: DOCK4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DOCK4
• Gene Alias: 5330406C03; 6330411N01Rik; AF263288; C030023J22; dedicator of cytokinesis 4; dedicator of cytokinesis protein 4; DOCK4; Kiaa0716; mKIAA0716; RGD1561724
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9732
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N1I0
• Gene Symbols: DOCK4
• Immunogen: Recombinant Human DOCK4. Recombinant protein control fragment (Product #RP-107821).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG