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Invitrogen™ DOK6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101187

Catalog No. PIPA5101187


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Description

Description

Antibody detects endogenous levels of total DOK6.

DOK-6 (docking protein 6), is a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway. (Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem. 2004 Oct 1;279(40):42072-81. Epub 2004 Jul 30. It is also known as DOK6, HsT3226, MGC20785 or IRS. 0.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DOK6
Polyclonal
Unconjugated
Dok6
Docking protein 6; DOK5L; Dok6; Dok-6; Downstream of tyrosine kinase 6; downstream of tyrosine kinases 6; HsT3226; RGD1564376
Rabbit
Affinity Chromatography
RUO
220164, 623279
-20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q2MHE5, Q6PKX4
Dok6
A synthesized peptide derived from human DOK6(Accession Q6PKX4), corresponding to amino acid residues E110-T160.
100 μL
Primary
Human, Mouse
Antibody
IgG
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