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Tocris Bioscience™ Dooku 1
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Catalog No. 656810
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65-681-0 10 mg
65-685-0 50 mg
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Catalog No. 65-681-0 Supplier Tocris Bioscience™ Supplier No. 6568/10
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Description

Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity

Dooku 1 reversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ∼1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonizes Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.

Specifications

Chemical Name or Material 2-[(2,6-Dichlorobenzyl)thio)-5-(1 H-pyrrol-2-yl)-1,3,4-oxadiazole
CAS 2253744-54-4
Quantity 10 mg
Target Other Piezo Channel Compounds
Molecular Formula C13H9Cl2N3OS
Formula Weight 326.2
Purity 98%
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