Tocris Bioscience™ Dorsomorphin dihydrochloride

Description

Potent AMPK inhibitor

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and Metformin (Cat. No. 2864). Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.

Specifications

Chemical Identifiers

• CAS: 1219168-18-9
• Molecular Formula: C24H27Cl2N5O

• Quantity: 50 mg
• Formula Weight: 472.41
• Purity: >98%
• Molecular Weight (g/mol): 472.414
• Chemical Name or Material: Dorsomorphin dihydrochloride

Safety and Handling

Recommended Storage

Desiccate at Room Temperature