Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIMA538325

Invitrogen™ Dot1L Recombinant Rabbit Monoclonal Antibody (3B6)
GREENER_CHOICE

Catalog No. PIMA538325
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIMA538325 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIMA538325 Supplier Invitrogen™ Supplier No. MA538325
Add to Cart
Add to Cart

Description

Rabbit Recombinant Monoclonal Antibody

This antibody has been tested in direct-ELISA.

DOT1-like histone lysine methyltransferase (DOT1L) is a gene located on chromosome 19q13.12, encoding an enzyme responsible for methylating lysine 79 on histone H3, a critical modification influencing chromatin structure and gene expression. Unlike most histone methyltransferases, DOT1L does not contain a SET domain and uniquely catalyzes H3K79 methylation, which plays pivotal roles in the regulation of transcription and maintenance of genomic stability. Expression of DOT1L is vital for various biological processes, including cell cycle progression, development, and differentiation, particularly in hematopoietic cells. Aberrations in DOT1L activity have been associated with mixed-lineage leukemia (MLL), where DOT1L-mediated H3K79 methylation contributes to leukemogenesis by influencing gene expression related to proliferation and survival. Due to its involvement in cancer progression, DOT1L is being investigated as a therapeutic target, with inhibitors developed to specifically modulate its enzymatic activity, offering potential for treating MLL and other malignancies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dot1L
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 3B6
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Dot1l
Gene Accession No. Q8TEK3
Gene Alias A630076O07; AW907654; DKFZp586P1823; DOT1; DOT1 like histone H3K79 methyltransferase; DOT1 like histone lysine methyltransferase; DOT1L; DOT1-like histone H3 methyltransferase; DOT1-like histone H3K79 methyltransferase; DOT1-like protein; DOT1-like, histone H3 methyltransferase; DOT1-like, histone H3 methyltransferase (S. cerevisiae); H3-K79-HMTase; histone H3 methyltransferase DOT1; histone H3-K79 methyltransferase; histone methyltransferase DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific; KIAA1814; KMT4; lysine N-methyltransferase 4; mDot1
Gene Symbols Dot1l
Host Species Rabbit
Immunogen A synthesized peptide derived from human KMT4Dot1L (aa 24-38).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84444
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.