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Invitrogen™ Dot1L Polyclonal Antibody
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Catalog No. PIPA582437
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100 μL
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PIPA582437 100 μL
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Catalog No. PIPA582437 Supplier Invitrogen™ Supplier No. PA582437
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LLKARCEELQ LDWATLSLEK LLKEKQALKS QISEKQRHCL ELQISIVELE KSQRQQELLQ LKSCVPPDDA LSLHLRGKGA LGRELEPDAS RLHLELDCTK FSLPHLSSMS PELSMNGQAA GYELCGVLSR PSSKQNTPQY LASPLDQ Highest antigen sequence indentity to the following orthologs: Mouse - 88%, Rat - 89%.

DOT1-like histone lysine methyltransferase (DOT1L) is a gene located on chromosome 19q13.12, encoding an enzyme responsible for methylating lysine 79 on histone H3, a critical modification influencing chromatin structure and gene expression. Unlike most histone methyltransferases, DOT1L does not contain a SET domain and uniquely catalyzes H3K79 methylation, which plays pivotal roles in the regulation of transcription and maintenance of genomic stability. Expression of DOT1L is vital for various biological processes, including cell cycle progression, development, and differentiation, particularly in hematopoietic cells. Aberrations in DOT1L activity have been associated with mixed-lineage leukemia (MLL), where DOT1L-mediated H3K79 methylation contributes to leukemogenesis by influencing gene expression related to proliferation and survival. Due to its involvement in cancer progression, DOT1L is being investigated as a therapeutic target, with inhibitors developed to specifically modulate its enzymatic activity, offering potential for treating MLL and other malignancies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dot1L
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Dot1l
Gene Accession No. Q8TEK3
Gene Alias A630076O07; AW907654; DKFZp586P1823; DOT1; DOT1 like histone H3K79 methyltransferase; DOT1 like histone lysine methyltransferase; DOT1L; DOT1-like histone H3 methyltransferase; DOT1-like histone H3K79 methyltransferase; DOT1-like protein; DOT1-like, histone H3 methyltransferase; DOT1-like, histone H3 methyltransferase (S. cerevisiae); H3-K79-HMTase; histone H3 methyltransferase DOT1; histone H3-K79 methyltransferase; histone methyltransferase DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific; KIAA1814; KMT4; lysine N-methyltransferase 4; mDot1
Gene Symbols Dot1l
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DOT1L. Recombinant protein control fragment (Product #RP-105721).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84444
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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