Invitrogen™ Doublecortin Monoclonal Antibody (3E1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA547314

Catalog No. PIMA547314

Description

Doublecortin Monoclonal Antibody for Western Blot, ICC/IF, IHC

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

Specifications

• Antigen: Doublecortin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 5mM sodium azide
• Gene Accession No.: O43602, O88809, Q9ESI7
• Gene Symbols: DCX
• Immunogen: Recombinant full length human Lis-A isoform of doublecortin expressed in and purified from E. coli.
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: 3E1
• Conjugate: Unconjugated
• Gene: DCX
• Gene Alias: DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 13193, 1641, 84394
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid