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Invitrogen™ Doublecortin Polyclonal Antibody
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Catalog No. PIPA5113728
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PIPA5113728 100 μL
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Catalog No. PIPA5113728 Supplier Invitrogen™ Supplier No. PA5113728
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PEKFRYAQDD FSLDENECRV MKGNPSATAG PKASPTPQKT SAKSPGPMRR For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%.

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Doublecortin
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene DCX
Gene Accession No. O43602, O88809
Gene Alias DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
Gene Symbols DCX
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C terminal region of human DCX (aa 254-303).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13193, 1641
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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