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Invitrogen™ Doublecortin Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142704

Catalog No. PIPA5142704


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Description

Description

Additional Information: This antibody is expected to recognize reported isoform a (NP_000546.2) only. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Doublecortin
Polyclonal
Unconjugated
DCX
DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
Goat
Ammonium sulfate precipitation
RUO
1641
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
O43602
DCX
Peptide with sequence DRSHCQSLRFHQN.
100 μg
Primary
Human
Antibody
IgG
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