Doublecortin Polyclonal Antibody, Rockland™

Goat Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-1582	Rockland Immunochemicals 600101MH8S	25 μg
50-199-1581	Rockland Immunochemicals 600101MH8	100 μg

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against human Neuronal migration protein doublecortin. Blast analysis the immunogen sequence shows 100% identity withrat.

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

Specifications

• Antigen: Doublecortin
• Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Host Species: Goat
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O43602, O88809, Q9ESI7
• Gene ID (Entrez): 13193, 1641, 84394
• Primary or Secondary: Primary
• Product Type: Antibody

• Concentration: 0.79 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Alias: BOS_25702; DBCN; Dbct; DC; Dcn; Dcx; doublecortex; doublecortin; Doublin; Lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
• Gene Symbols: DCX
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: DCX