Invitrogen™ Doublecortin Recombinant Rabbit Monoclonal Antibody (BLR168J)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544522

Catalog No. PIMA544522

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

Specifications

• Antigen: Doublecortin
• Classification: Recombinant Monoclonal
• Concentration: 50 μg/mL
• Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
• Gene Accession No.: O43602
• Gene Symbols: DCX
• Immunogen: Peptide representing a region between residue 200 and 250 of Human Doublecortin.
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: BLR168J
• Conjugate: Unconjugated
• Gene: DCX
• Gene Alias: DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
• Host Species: Rabbit
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 1641
• Content And Storage: 4°C
• Form: Liquid