Thermo Scientific Chemicals Doxorubicin hydrochloride, 10 mg/ml in distilled water, sterile filtered

Catalog No.	Quantity
AAJ67364XF	1 mL

Catalog No. AAJ67364XF Supplier Thermo Scientific Chemicals Supplier No. J67364XF

Description

CAS: 25316-40-9 | C27H30ClNO11 | 579.98 g/mol

It acts as an antitumor antibiotic agent that inhibits DNA topoisomerase II and acts as a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. It reduces intracellular tau levels. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein. It is an is an inhibitor of AMPK, TERT and POLR. its fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. It is applied as an antineoplastic.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It acts as an antitumor antibiotic agent that inhibits DNA topoisomerase II and acts as a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. It reduces intracellular tau levels. By intercalating within DNA,

Specifications

Chemical Identifiers

• CAS: 25316-40-9
• Molecular Formula: C27H30ClNO11
• Molecular Weight (g/mol): 579.98
• MDL Number: MFCD00077757,MFCD00077757,MFCD00941448
• InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N
• PubChem CID: 129626538
• IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride
• SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O

• Type: Doxorubicin Hydrochloride
• Physical Form: Liquid
• Quantity: 1 mL
• Solubility Information: Fully miscible in water and soluble in 50 mM in DMSO,methanol and isotonic sodium chloride (>10mg/ml). Insoluble in chloroform,and ether.
• Chemical Name or Material: Doxorubicin hydrochloride, 10mg/mL in distilled water, sterile-filtered

Safety and Handling

Hazard Category	H319-H340-H350-H361
Hazard Statement	GHS H Statement H350 May cause cancer.
Precautionary Statement	P201-P202-P264b-P280i-P281-P305+P351+P338-P308+P313-P501c
EINECSNumber	246-818-3
RTECSNumber	QI9295900
TSCA	No
storageNote1	-30° to -10°C
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only