Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ Doxorubicin hydrochloride

Tocris Bioscience™ Doxorubicin hydrochloride
GREENER_CHOICE

Catalog No. 225250
Change view
Click to view available options
Quantity:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
22-525-0 50 mg
22-521-0 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Catalog No. 22-525-0 Supplier Tocris Bioscience™ Supplier No. 2252/50
Only null left
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Antitumor antibiotic agent. Inhibits DNA topoisomerase II

Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin (Cat. No. 1467) that is naturally fluorescent. Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II. It is a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Doxorubicin reduces intracellular tau levels. Doxorubicin also promotes formation of free radicals for the disruption of membrane lipids and DNA strands. Doxorubicin fluorescence is quenched upon intercalation into the DNA; while binding to histones or partitioning into the phospholipid phase of PEG-phospholipid micelles or hydrophobic cores of polymeric micelles, increases Doxorubicin fluorescence. Doxorubicin fluorescence enables the monitoring of the localization of the drug within lipid bilayers and liposomal delivery systems and interaction of the drug with DNA and other macromolecules, as well as drug efflux pump activities.

Chemical Identifiers

CAS 25316-40-9
Molecular Formula C27H30ClNO11

Specifications

Quantity 50 mg
Formula Weight 579.99
Purity >98%
Molecular Weight (g/mol) 579.98
Chemical Name or Material Doxorubicin hydrochloride

Safety and Handling

Recommended Storage Desiccate at Room Temperature
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.