Invitrogen™ DPF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531430

Catalog No. PIPA531430

Description

Recommended positive controls: NT2D1, IMR32, U87-MG. Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (84%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Specifications

• Antigen: DPF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DPF1
• Gene Alias: Baf45b; BRG1-associated factor 45B; D4, zinc and double PHD fingers family 1; double PHD fingers 1; DPF1; NEU BAF45b; NEUD4; neuro-d4; neuro-d4 homolog; neuronal d4 domain family member; zinc finger protein neuro-d4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8193
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.85 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q92782
• Gene Symbols: DPF1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human DPF1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG