Invitrogen™ DPPA2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5141186

Catalog No. PIPA5141186

Description

DPPA2 Polyclonal Antibody for Western Blot, IHC (P)

The DPPA2 (Developmental Pluripotency Associated 2) gene is prominently expressed in embryonic stem cells and is critical for maintaining their pluripotency and self-renewal capabilities. Located on chromosome 3, DPPA2 belongs to a family of genes that play significant roles in early embryonic development and epigenetic remodeling. The expression of DPPA2 is tightly regulated through mechanisms such as DNA methylation, and it is involved in regulatory pathways that control the expression of core pluripotency factors. Beyond its role in stem cell biology, DPPA2 expression is also noted in various cancers, where it can become reactivated, suggesting its involvement in oncogenic processes. In the context of cancer, DPPA2, along with DPPA4, has been studied for its potential to facilitate cellular reprogramming and contribute to tumorigenesis. Given its expression pattern, DPPA2 serves as both a marker of pluripotent potential in stem cells and a potential target for cancer diagnostics and therapy due to its reactivation in malignant tissues.

Specifications

• Antigen: DPPA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DPPA2
• Gene Alias: 2410088E07Rik; C80932; cancer/testis antigen 100; CT100; D19Mgi18; developmental pluripotency associated 2; developmental pluripotency-associated 2; developmental pluripotency-associated protein 2; DPPA2; ECAT15-2; ECSA; embryonic stem cell (ESC) associated transcript 15-2; embryonic stem cell-associated transcript 15-2 protein; LOC683282; PESCRG1; Phsecrg1; Pluripotent embryonic stem cell-related gene 1 protein; similar to developmental pluripotency-associated 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 73703
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.2% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9CWH0
• Gene Symbols: DPPA2
• Immunogen: Synthetic peptide within mouse DPPA2 aa 1-50/301.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG