Invitrogen™ DPPA4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589388

Catalog No. PIPA589388

Description

Immunogen sequence: KGKEWTSTEK SREEDQQASN QPNSIALPGT SAKRTKEKMS IKGSKVLCPK KKAEHTDNPR PQKKIPIPPL PSKLPPVNLI HRDILRAWCQ QLKLSSKGQK LDAYKRLCAF AYPNQKDFPS TAKEAKIRKS LQKKLKVEKG ETSLQSSETH PPEVALPPVG EPPALENSTA LLEGVNTVVV TTSAPEALLA SWARISARAR TPEAVESPQE ASGVRWCVVH GKSLPADTDG WVHLQFHAGQ AWVPEKQEGR VSALFLLPAS NFPPPHLEDN MLCPKCVHRN KVLIKSLQWE; Positive Samples: LO2, Mouse testis, Rat testis; Cellular Location: Nucleus.

The DPPA4 gene encodes developmental pluripotency associated 4, a protein that plays a crucial role in maintaining stem cell pluripotency and facilitating early embryonic development. DPPA4 is primarily expressed in pluripotent stem cells, such as embryonic stem cells, where it contributes to the regulation of gene expression and chromatin structure necessary for pluripotency and differentiation. This protein is also involved in the establishment of epigenetic marks that influence developmental pathways, ensuring the proper formation of tissue types during embryogenesis. DPPA4 functions in stem cell renewal and differentiation, impacting cellular processes that are fundamental to early development. Beyond its roles in normal physiology, DPPA4 has been studied in the context of oncology, where its expression is often upregulated in certain cancers, indicating its potential as a biomarker for tumorigenic stem cell-like properties. Research continues to explore DPPA4's mechanisms and interactions to understand its contributions to development and its implications in disease states, particularly in cancer biology and regenerative medicine.

Specifications

• Antigen: DPPA4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DPPA4
• Gene Alias: 2410091M23Rik; C76608; developmental pluripotency associated 4; developmental pluripotency-associated protein 4; Dppa4; ECAT15-1; Embryonic stem cell-associated transcript 15-1 protein; LOC685378; similar to developmental pluripotency associated 4 isoform 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55211, 685378, 73693
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.61 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: D3Z8Y2, Q7L190, Q8CCG4
• Gene Symbols: DPPA4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 15-304 of human DPPA4 (NP_0606593).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov