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DPPL1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501987155
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50-198-7155 100 μL
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Catalog No. 50-198-7155 Supplier Bioss Supplier No. BS6250R
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Description

Rabbit Polyclonal Antibody

Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.

Specifications

Antigen DPPL1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene PLPP5
Gene Accession No. Q8NEB5
Gene Alias 1810019D05Rik; 2310022A04Rik; AW045471; diacylglycerol pyrophosphate like 1; diacylglycerol pyrophosphate phosphatase-like 1; DPPL1; HTPAP; phosphatidate phosphatase PPAPDC1B; phosphatidic acid phosphatase type 2 domain containing 1; phosphatidic acid phosphatase type 2 domain containing 1B; Phosphatidic acid phosphatase type 2 domain-containing protein 1B; Phospholipid phosphatase 5; PLPP5; Ppapdc1; PPAPDC1B; testicular secretory protein Li 38
Gene Symbols PLPP5
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human DPPL1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84513
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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