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Tocris Bioscience™ DPTIP
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Catalog No. 690310
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Catalog No. Quantity
69-031-0 10 mg
69-035-0 50 mg
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Catalog No. 69-031-0 Supplier Tocris Bioscience™ Supplier No. 6903/10
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Description

Potent and selective N-SMase2 inhibitor; brain penetrant

DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.

Specifications

Quantity 10 mg
Molecular Formula C21H18N2O3S
Formula Weight 378.45
Product Type Inhibitor
Purity 98%
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