Invitrogen™ DR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589144

Catalog No. PIPA589144

Description

Immunogen sequence: MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNK SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK RRKASSRLEN LGIPEEELLR QQQELFAKAR QQQAELAQQE WLQMQQAAQQ AQLAAASASA SNQAGSSQDE EDDDDI; Positive Samples: Mouse spleen; Cellular Location: Nucleus.

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Specifications

• Antigen: DR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dr1
• Gene Alias: 1700121L09Rik; Down-regulator of transcription 1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); Dr1; Dr1l; NC2; NC2B; NC2beta; NC2-beta; negative cofactor 2; negative cofactor 2 beta; negative cofactor 2-beta; Protein Dr1; similar to down-regulator of transcription 1; TATA-binding protein-associated phosphoprotein; wu:fj15f04; zgc:152914
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13486, 1810
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.92 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q01658, Q91WV0
• Gene Symbols: Dr1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_0019291).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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